Shots - Health News
2:49 pm
Fri December 21, 2012

Killer's DNA Won't Explain His Crime

Originally published on Fri December 21, 2012 8:21 pm

Connecticut's chief medical examiner, Wayne Carver, has raised the possibility of requesting genetic tests on Adam Lanza, the man responsible for the shootings at Sandy Hook Elementary School.

Carver hasn't said precisely what he may want geneticists to look for, but scientists who study the links between genes and violence say those tests won't reveal much about why Lanza did what he did.

Ellen Wright Clayton, a specialist in law and genetics at Vanderbilt University, says there aren't many possibilities. "The only thing they can be looking for here is to see whether the killer had certain genetic variants that may predispose to mental illness or to violence," she says.

Scientists have spent decades studying these genetic variants. But can a person's genes reveal why they commit mass murder?

"Absolutely not," Clayton says. "Genetic variants do not explain criminal behavior."

The strongest genetic link to aggressive behavior involves a gene known as MAOA. About a decade ago, Clayton says, researchers studied children with a particular variation in this gene.

"What they showed there was that kids who had the adverse genotype and who were also exposed to severe child abuse were more likely to have bad behavior as adults," she explains.

Other studies have confirmed that the gene variant by itself isn't a good predictor of violence. It only makes a real difference in people who carry the gene and were abused as children.

And of course the vast majority of people with the variant don't commit violent crimes.

Despite these caveats, evidence involving MAOA has been used in court. Some lawyers have argued that violent offenders who carry the gene should be held less responsible for their actions.

But the reaction of the courts has been mixed. "In some cases they have accepted it to mitigate penalties," Clayton says. "But in many cases they've decided that it's not pertinent for that purpose."

Other scientists say they also don't expect much from any genetic analysis of Lanza.

"It's not likely that they'll get any definitive answer. What they may get are some clues," says criminologist Adrian Raine, who studies antisocial behavior at the University of Pennsylvania.

Raine agrees with Clayton that one of those clues could involve the MAOA gene variant. But there's a hitch when it comes to Lanza. MAOA is associated with abnormalities in the brain that can result in so-called impulsive aggression — when a person throws a punch or pulls a gun in the heat of the moment.

"People who are impulsive and reactively aggressive have lower functioning in the very frontal region of the brain," Raine says. "In contrast those who plan and regulate their aggressive behavior, they do not have that specific brain abnormality."

That means MAOA isn't so good at explaining a premeditated mass murder.

Genetic analysis also can suggest whether a person is predisposed to developing depression, bipolar disorder, schizophrenia or autism, Raine says. But just having certain genes doesn't mean a person is destined to get any of these disorders. So any definitive diagnosis will require other types of information.

"Those clues will be more readily obtained from teachers, friends, relatives. That will certainly yield more information than genetic material," Raine says.

One reason researchers don't know more about genes and mass murder is that this sort of crime makes up only a tiny fraction of all homicides.

"We are looking at very rare behaviors. And from a scientific point of view we really don't study them in any systematic way," says Kevin Beaver, a criminologist at Florida State University.

Nonetheless, Beaver says he understands why people are desperately searching for answers after an event like the shootings at Sandy Hook Elementary.

"We want explanations. We want to understand why someone did this," he says. "But from a scientific standpoint, I don't think we would ever know why someone would engage in this type of horrific, violent behavior that's aimed at very young children."

That's not surprising. Researchers still haven't definitively explained what led to mass killings in Aurora, Blacksburg, or Columbine.

Copyright 2012 National Public Radio. To see more, visit http://www.npr.org/.

Transcript

ROBERT SIEGEL, HOST:

From NPR News, this is ALL THINGS CONSIDERED. I'm Robert Siegel.

MELISSA BLOCK, HOST:

And I'm Melissa Block. After the shootings in Newtown, Connecticut, authorities, victims' families and the general public are left to wonder why. Connecticut's chief medical examiner has raised the possibility of requesting genetic tests on the gunman, Adam Lanza. But scientists who study the links between genes and violence say those tests likely won't help in the search for answers. NPR's Jon Hamilton reports.

JON HAMILTON, BYLINE: The medical examiner, Wayne Carver, hasn't said precisely what he may want geneticists to look for but Ellen Wright Clayton of Vanderbilt University says there aren't many possibilities.

ELLEN WRIGHT CLAYTON: The only thing they can be looking for here is to see whether the killer had certain genetic variants that may predispose to mental illness or to violence.

HAMILTON: Clayton says scientists have spent decades studying these genetic variants but can a person's genes reveal why they commit mass murder?

CLAYTON: No, absolutely not. Genetic variants do not explain criminal behavior.

HAMILTON: Clayton says the strongest genetic link to aggressive behavior involves a gene known as MAOA. About a decade ago, she says, researchers studied children with a particular variation in this gene.

CLAYTON: What they showed there was that kids who have the adverse genotype and who were also exposed to severe child abuse were more likely than all other kids to have bad behavior as adults.

HAMILTON: Other studies have confirmed the gene variant by itself isn't a good predictor of violence. It only makes a real difference in people who carry the gene and were abused as children. And, of course, the vast major of people with the variant don't commit violent crimes. Despite these caveats, evidence involving MAOA has been used in court. Some lawyers have argued that violent offenders who carry the gene should be held less responsible for their actions. Clayton says the reaction of courts has been mixed.

CLAYTON: In some cases they have accepted it to mitigate penalties. But in many cases, they've decided that it's not pertinent for that purpose.

HAMILTON: Other scientists say they don't expect much from any genetic analysis of Adam Lanza. Adrian Raine studies antisocial behavior at the University of Pennsylvania.

ADRIAN RAINE: It's not likely that they'll get any definitive answer. What they may get are some clues.

HAMILTON: Raine agrees with Clayton that one of those clues could involve the MAOA gene variant. But there's a hitch when it comes to Adam Lanza. Raine says MAOA is associated with abnormalities in the brain that can result in so-called impulsive aggression, when a person throws a punch or pulls a gun in the heat of the moment.

RAINE: People who are impulsive and reactively aggressive have lower functioning in the very frontal region of the brain. In contrast, those who plan and regulate their aggressive behavior, they do not have that specific brain abnormality.

HAMILTON: Which means MAOA isn't so good at explaining a premeditated mass murder. Raine says a genetic analysis also can suggest whether a person is predisposed to develop depression, bipolar, schizophrenia or autism. But just having certain genes doesn't mean you're destined to get any of these disorders. So, Raine says any definitive diagnosis will require other types of information.

RAINE: Those clues will be more readily obtained from teachers, friends, relatives. That will certainly yield more information than genetic material.

HAMILTON: Researchers say one reason they don't know more about genes and mass murder is that this sort of crime makes up only a tiny fraction of all homicides. Kevin Beaver is a criminologist at Florida State University.

KEVIN BEAVER: We're looking at very rare behaviors. And from a scientific standpoint they're so rare that we really don't study them in any systematic way.

HAMILTON: Nonetheless, Beaver says he understands why people are desperately searching for answers after an event like the shooting at Sandy Hook Elementary.

BEAVER: We want explanations. We want to understand why someone did this. But from a scientific standpoint I don't think we would ever know why someone would engage in this type of horrific, violent behavior that's aimed at very young children.

HAMILTON: That's not surprising. Researchers still haven't definitively explained what led to mass killings in Aurora, Blacksburg or Columbine. Jon Hamilton, NPR News. Transcript provided by NPR, Copyright National Public Radio.

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